02. 2014年7月26日 08:53:20
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なるほどimmature の場合は、逆相関が見える1000Bq/kgだと40を超えるものが見えないところを見ると 何らかの造血細胞の分化を阻害する効果があるのかもしれない 今後は、発がん率などとの相関も調べるべきだろう あとヒトで、これほど高度に被曝した例はほとんどないだろうが
血液検査で網羅的に相関を調べてみる価値はあるな http://www.nature.com/srep/2014/140724/srep05793/fig_tab/srep05793_F2.html White blood cell counts and muscle radiocesium concentrations in immature Japanese monkeys captured in Fukushima. Table 3: Correlation between muscle radiocesium concentration and hematological values in Fukushima monkeys From Low blood cell counts in wild Japanese monkeys after the Fukushima Daiichi nuclear disaster Kazuhiko Ochiai, Shin-ichi Hayama, Sachie Nakiri, Setsuko Nakanishi, Naomi Ishii, Taiki Uno, Takuya Kato, Fumiharu Konno, Yoshi Kawamoto, Shuichi Tsuchida & Toshinori Omi Scientific Reports 4, Article number: 5793 doi:10.1038/srep05793 Received 06 February 2014 Accepted 24 June 2014 Published 24 July 2014 back to article Table 3: Correlation between muscle radiocesium concentration and hematological values in Fukushima monkeys RBC Hb Ht Cs n r p n r p n r p n r p Pearson's correlation coefficient (r) was calculated to show correlation between muscle radiocesium concentrations and hematological values for each age group. WBC, white blood cell count; RBC, red blood cell count; Hb, hemoglobin; Ht, hematocrit; Cs, muscle radiocesium concentration; n, number of individuals; p, p values. Immature WBC 22 0.430 0.045 21 0.501 0.021 22 0.526 0.012 23 −0.520 0.011 RBC 22 0.967 5 years). Furthermore, we calculated fat indices to evaluate monkeys' nutritional status. In the previous study20, the ratio of mesenteric fat weight to body weight is proportional to the percentage of body fat in Japanese monkeys. The fat index was defined as mesenteric fat weight (g) divided by body weight (g), multiplied by 1000. Measurements of radioactivity The radioactivity of radiocesium of muscle samples was analyzed using a germanium semiconductor spectrometer (Canberra, GC2020-7500SL-2002CSL, Meriden, CT) and a NaI (T1) scintillation detector (Atometex, AT1320A, Minsk, Belarus). Data were corrected to background radiation dose in the measurement environment on an as-needed basis. 134Cs was detected using 604.70- and 795.85-keV gamma-ray energies, while 137Cs was detected using 661.6-keV gamma-ray energies. The radioactivity of radiocesium was adjusted to the value on the day of capture based on its physical half-life. The limit of detection was 10 Bq/kg. Muscle cesium concentration was calculated as the combined concentration of 134Cs and 137Cs per kg fresh weight muscle. Statistics Data were analyzed using SPSS 10.0 for Windows (SPSS Inc., Chicago, Illinois, USA). Two-way ANOVA was used to compare hematological values and fat index with areas and age as factors. The Tukey–Kramer method was used to perform multiple comparisons of hematological values between groups. Pearson's correlation coefficient was used to examine correlations between muscle cesium concentration and hematological values. References Introduction• Results• Discussion• Methods• References• Acknowledgements• Author information Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) website. 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Article Show context Download references Acknowledgements Introduction• Results• Discussion• Methods• References• Acknowledgements• Author information This study was made possible by the cooperation of Fukushima City, Mr. Hideharu Yamazaki, and Dr. Noriaki Shibata. The authors would like to express their sincere thanks to all those involved in this study. We would also like to express our deepest gratitude to members of Nippon Veterinary and Life Science University for their critical assistance in the study. The present study was supported by the following funding sources: Cooperative Research Program of the Primate Research Institute, Kyoto University, and Science Research Promotion Fund from the Promotion and Mutual Aid Corporation for Private Schools in Japan. Author information |
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