SARSで過剰な免疫応答による強い炎症を起こしやすいアジア・アフリカ系：白人には起きにくい【あくまで仮説】

SARSで過剰な免疫応答による強い炎症を起こしやすいアジア・アフリカ系：白人には起きにくい【あくまで仮説】
http://www.asyura.com/0304/health4/msg/224.html
投稿者青虫日時 2003 年 4 月 23 日 00:14:39:2U1GpFQHf/sOo

http://www.rense.com/general37/SARStreatmentideas.pdf

SARSの治療法についての仮説(免疫応答の抑制案)を提示する論文ですが、コーカシアンにくらべると、アジア、アフリカ系がSARSに感染しやすく死亡しやすいことについて、スペキュレーションが行われていました。

So then, if there are ethnic differences relative to the Fc gamma Receptors associated with IgG and incidence of infectious and autoimmune diseases, might this serve as a basis whereby it might be possible to understand SARS?

Let’s consider the situation in SARS coronavirus and the currently developing pandemic. At this point, there have been over a thousand Chinese infected with SARS and the mortality rate hovers around 5% of that population. In contrast, Caucasian-predominate nations have very few cases of SARS and, for example, in the United States no one has died from SARS. While the disease is not widely spread in Caucasian countries at this time (those infected in Toronto are predominately Chinese), there may be some reason to consider ethnicity and differential immune-system functioning in response to disease.

Might this difference in ethnicity-number-dead-and-infected be a function of an “influencing of differences in the incidence rates of infectious and autoimmune diseases” suggested above? This might depend on whether SARS coronavirus activates Fc gamma Receptors in Asian and Africans who may have a disproportionate proinflammatory reaction to SARS. This remains to be seen as the science progresses. However, we might expect that this potent proinflammatory reaction might be due to the SARS coronavirus and perhaps this potent proinflammatory reaction is associated with Fc gamma Receptors. It is a theory worth investigating.

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